During aging, human skin undergoes significant alterations of its biomechanical properties and a loss of elasticity that results in skin sagging. Dermal elastic fibers represent the primary components that support tissue compliance and resilience, but as time goes by, their organization and functionality decline, which makes them a preferred target for cosmetic anti-aging strategies.   The current 3D bioengineered skin substitutes, which are easily  available on the market, are still defective m...